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Custom Synthesis
Custom Synthesis
Lead Sciences provides reliable custom chemical synthesis and contract research services
Lead Sciences’ scientists are skilled in the latest methods in synthetic organic chemistry. We ensure the delivery of high-quality products in a timely manner. Our scientists focus efforts to evaluate the synthesis. Your inquiries will be addressed within 48 hours upon receipt. We will offer a ballpark price and a lead time for the project. Lead Sciences honors its quoted price even when the project might require more work than anticipated. We won’t charge our clients for failed syntheses.
What we offer
- Value added customized synthesis
- Expert project planning and management
- Development of new synthetic routes
- Customized cocktail of chemicals
- Milligram to kilogram batch synthesis capacity
- Fully developed purification and analytical capabilities
Our custom synthesis specialties includes
- Delivering custom synthesis at off the shelf pricing
- Process research, development and optimization
- Small and large scale chemistry capabilities
- Synthetic route design and optimization
- Advanced synthetic and analytical platform
- Cost-effective and high efficiency
Custom synthesis chemical documents are available:
- Synthesis procedure (original synthesis records, TLC, etc), high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance analyses (NMR), etc.
- With state-of-the-art laboratories, equipped with the latest process and analytic instruments, LEAD Sciences’ scientists have good experience and infrastructure to make your project a success.
Custom synthesis Workflow
Our custom synthesis services include, but are not limited to, the following:
Nucleosides Synthesis & Nucleotides Synthesis:
Nucleosides are important biological molecules that function as signaling molecules and as precursors to nucleotides needed for DNA and RNA synthesis. Drugs-based nucleotides are an emerging field in recent years. Nucleotide drugs are a variety of oligonucleotides (RNA) or oligodeoxyribonucleotides (DNA) with different functions, which have specific targets and mechanisms of action, so nucleotide drugs have a wide range of application prospects.
API Synthesis
Active pharmaceutical ingredient (API) is an active ingredient in a pharmaceutical product. This substance has a pharmacological activity or other direct effects in the diagnosis, treatment, symptom relief, management or prevention of disease, or can affect the function or structure of the organism.
Asymmetric Synthesis:
Asymmetric synthesis, also known as chiral synthesis or enantioselective synthesis, is the branch of organic synthesis in which one or more chiral elements are introduced to the reactants via a chemical reaction. Asymmetric synthesis has a very important place in both drug synthesis and total synthesis of natural products, and has great importance in the screening of APIs and development of bio/pharmaceutical products.
Radiolabeled Chemical Synthesis:
Recognizing the increasing importance of radiometric detection in drug discovery and development, radiolabeled chemical synthesis is hence become a highly concerned area in the pharmaceutical industry.
Heterocyclic compounds Synthesis:
Heterocyclic compounds are organic compounds that contain a heterocyclic structure in the molecule. The atoms that make up the ring contain at least one heteroatom in addition to the carbon atom. The most common heteroatoms are nitrogen, sulfur and oxygen atoms. Heterocyclic compounds can be divided into two categories, alicyclic and aromatic heterocyclic. Heterocyclic compounds are commonly found in the structure of drug molecules.
Bioconjugation
Bioconjugation represents the technique of giving a target substance with certain desired properties through the site-specific reaction between the biomolecules and exogenous moieties (usually one or several other molecules). Through such a covalent linkage approach, a broad range of innovative drug substances or end products is designed to improve the accuracy of disease diagnosis, pharmacokinetic properties, treatment efficacy and many other aspects.
Peptide Synthesis
Peptides are the bioactive substance related to various cellular functions in living organisms, consisting of multiple amino acids bound by peptide bonds in a certain order of arrangement. Peptides are often used in functional analysis, antibody research, and especially in drug development.
Process R&D:
An effective process R&D is an essential part of your drug development while it plays important role in controlling costs, ensuring product’s quality and meeting the requirements of regulations. More importantly, package solutions are available to address any problems and potential risks that significantly impact the quality of your products.
Other Synthesis Services:
- Polycyclic Aromatic Hydrocarbons Synthesis
- Carbohydrate Synthesis
- Steroids Synthesis
- Flavors-fragrance Synthesis
- Semi-synthesis and Total Synthesis of Natural Products
Our chemical synthesis capabilities:
- Synthetic Route Design and Optimization
- Process Research, Development, and Optimization
- Small- and Large-Scale Chemistry Capabilities
- Advanced Synthetic and Analytical Platform
- Expert Project Management
- Cost-Effectiveness and High Efficiency
Common chemical reactions and purposes:
| Reaction | Purpose |
| Michael addition | Alkylation of reactive methylene, Robinson annelation |
| Aldol condensation | Preparation of α,β-unsaturated aldehydes and ketones or acid esters |
| Friedel-Crafts reaction | Preparation of aromatic ketones |
| Asymmetric hydrogenation | Hydrogenation and generation of chiral centers |
| Nucleophilic fluorination | Preparation of organic fluorine compound |
| Suzuki coupling | Generation of C-C bond |
| Buchwald–Hartwig reaction | Generation of C-N bond |
| Knoevenagel condensation reaction | Preparation of α,β-unsaturated compounds |
| Mannich reaction | Preparation of β-amino compounds |
| Wittig Reaction | Direct synthesis of olefins from aldehydes and ketones . |